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Lepu Medical – Test Sierologico Rapido 2019-nCoV Neutralization Antibody Kit – Colloidal Gold (CE IVD)

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Lepu Medical – Test Sierologico Rapido 2019-nCoV Neutralization Antibody Kit – Colloidal Gold (CE IVD)

149,00

Confezione da 20 test

Il test 2019-nCoV Neutralization Antibody viene utilizzato per rilevare qualitativamente la presenza degli Anticorpi di neutralizzazione 2019-nCoV in ambito clinico su campioni di siero, plasma e sangue intero.

IVA 5% ai sensi dell’art. 124 D.L. 19 maggio 2020, n. 34 Parte II-bis 1-ter.1.

Descrizione

Il test 2019-nCoV Neutralization Antibody viene utilizzato per rilevare qualitativamente la presenza degli Anticorpi di neutralizzazione 2019-nCoV in ambito clinico su campioni di siero, plasma e sangue intero.

Confezione da 20 test.

Questo prodotto rileva qualitativamente gli anticorpi di neutralizzazione 2019-nCoV in campioni in ambito clinico (siero / plasma / sangue intero)

IVA 5% ai sensi dell’art. 124 D.L. 19 maggio 2020, n. 34 Parte II-bis 1-ter.1.

Il risultato positivo indica la presenza di anticorpi neutralizzanti contro la proteina RBD di SARS-CoV-2. Ciò suggerisce il livello di immunità al COVID-19

Neutralizing Antibody Rapid Test Intended Use

The 2019 novel coronavirus (SARS-CoV-2) has several structural proteins, including spike (S), envelope (E), membrane (M), and nucleocapsid (N). The S-protein contains a receptor binding domain (RBD), which can recognize the cell surface receptor, angiotensin-converting enzyme-2 (ACE2). In a recent study, neutralizing antibody (NAb) can block the interaction between the receptor-binding domain (RBD) of the novel coronavirus spike protein with the ACE2 cell surface receptor. The level of NAb, therefore, can be used to analyze a patient’s immunity against future SARS-CoV-2 infection. This COVID-19 neutralizing antibody lateral flow assay rapidly detects any antibodies that can neutralize the RBD-ACE2 interaction.

Researchers have been using traditional viral neutralization assay for testing SARS-CoV-2 neutralizing antibodies and there are several ELISA based neutralizing antibody test kits available in the market since May 2020. However, performing COVID-19 neutralization assays or ELISA requires complex laboratory settings, and it is time-consuming, despite a higher sensitivity and specificity. This neutralizing antibody rapid test cassette provides an easy way for the preliminary screening of NAb to estimate patients’ immunity to novel coronavirus infection.

COVID-19 NAb Rapid Test Principle

COVID-19 neutralizing antibody test kit is a lateral flow assay for rapid NAb screening, which can mimics the virus neutralization process. This lateral flow assay contains two key components: the recombinant SARS-CoV-2 RBD fragment and chicken IgY, labeled by colloidal gold are as tracers; and the human ACE2 receptor protein (hACE2) and goat anti-chicken IgY antibody, coated with cellulose nitrate membrane. The protein-protein interaction between RBD and hACE2 can be blocked if the test samples contains a certain level of neutralizing antibody against SARS-CoV-2.

2019-nCoV Neutralization Antibody Test Kit per valutazione effetto vaccini
(Immagine puramente indicativa)

When specimens are added to the sample pad, neutralizing antibodies present in the specimen will bind to the RBD labeled colloidal gold and block the protein-protein interaction between RBD and hACE2. The unbound RBD labeled colloidal gold as well as any RBD labeled colloidal gold bound to non-neutralizing antibody will be captured on the test line. The colloidal gold labeled chicken IgY antibody is bound to the goat anti-chicken IgY antibody coated with a colored band (C line), which acts as a procedural quality control line.

2019-nCoV-Neutralization-Antibody-Test-Kit-–-For-Vaccines-effect-Evaluation---result-interpretation

2019-nCoV Neutralization Antibody Test Kit – Result Interpretation

  • POSITIVO: Purple red band appears in quality control area (C) and M/G test area
  • NEGATIVO: Purple red band only appears in quality control area (C)
  • INVALIDO: No purple stripe appears in the quality control area (C)

A positive result indicates you are likely to have had COVID-19 and have neutralizing antibodies against the RBD protein of SARS-CoV-2. This suggests you may have a level of immunity to COVID-19 (Vaccine Effect)

Informazioni aggiuntive

Scegli il confezionamento:

1 Box (20 test), Bundle 3 Box (60 test), Bundle 5 Box (100 test)

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